ABSORPTION, DISTRIBUTION AND ELIMINATION OF CEFAZOLIN IN PATIENTS WITH NORMAL RENAL-FUNCTION

被引：8

作者：

BERGAN, T

DIGRANES, A

SCHREINER, A

机构：

[1] UNIV BERGEN,MED DEPT B,N-5014 BERGEN,NORWAY

[2] UNIV BERGEN,GADE INST,DEPT MICROBIOL,BERGEN,NORWAY

来源：

CHEMOTHERAPY | 1978年 / 24卷 / 05期

关键词：

Cephalosporins Cefazolin Pharmacokinetics;

D O I：

10.1159/000237793

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cefazolin was given intramuscularly in a dosage of 1.0 g to 13 bed-ridden patients during treatment for various infections, and the pharmacokinetics evaluated in each subject. In 9 patients the mean serum half-life was 2.7 h, whereas in 4 patients-all over 60 years of age-it was significantly above this value. Impaired renal function could not explain the prolonged excretion time in the last group. © 1978 S. Karger AG, Basel.

引用

页码：277 / 282

页数：6

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