COMBINED THERAPY IN CHILDHOOD RHABDOMYOSARCOMA - AN ANALYSIS OF 42 CASES

Forty-two cases of rhabdomyosarcoma in infants and children are presented. The relation of survival to age, site, cell type, stage of disease and therapeutic management is evaluated. The majority of survivors are between one and 3 years, have localized disease of embryonal or alveolar cell type and have been treated with combined surgery, radiation and chemotherapy. Postoperative survival of 2 years without evidence of recurrence relates well to a cure. In instances of rhabdomyosarcoma in infants and children, radical operation, postoperative regional radiation in combination with simultaneous and prolonged repeated courses of Actinomycin D and Vincristine appear justified and are recommended. © 1970.