6-SUBSTITUTED 1-METHYLQUINOLINIUM-2-DITHIOACETIC ACID ZWITTERIONS - ANTI-LEUKEMIA ACTIVITY

被引：9

作者：

FOYE, WO

KAUFFMAN, JM

机构：

[1] Samuel M. Best Research Laboratory, Massachusetts College of Pharmacy, Boston, Massachusetts

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 03期

关键词：

Antileukemic activity—various quinolinium‐2‐dithioacetic acid zwitterions evaluated in mice; Dithioacetic acids; quinolinium—zwitterions synthesized; antileukemic activity evaluated in mice; Structure‐activity relationships—quinolinium‐2‐dithioacetic acid zwitterions evaluated for antileukemic activity in mice; Zwitterions—quinolinium‐2‐dithioacetic acids synthesized;

D O I：

10.1002/jps.2600680321

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Condensation of the anhydro bases derived from 6‐substituted 1‐methylquinaldinium iodides with carbon disulfide provided the 2‐dithioacetic acid zwitterions. Since 1,6‐dimethylquinolinium‐2‐di‐thioacetic acid zwitterion previously showed appreciable activity against P‐388 lymphocytic leukemia in mice, a series of analogs with other 6‐substituents was synthesized to assess the importance of substitution in this position. Both electron‐donating and electron‐attracting 6‐substituents gave compounds with antileukemia activity. The 6‐unsubstituted analog had only marginal activity. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：336 / 338

页数：3

共 16 条

[1]

BOOKER LGS, 1937, J AM CHEM SOC, V59, P67

[2] STUDIES IN THE QUINOLINE SERIES .5. THE PREPARATION OF SOME ALPHA-DIALKYLAMINOMETHYL-2-QUINOLINEMETHANOLS [J].