REGULATION OF DOPAMINE SYNTHESIS IN STRIATAL SYNAPTOSOMES DURING DEPOLARIZATION

被引：27

作者：

KAPATOS, G ^{[1
]}

ZIGMOND, MJ ^{[1
]}

机构：

[1] UNIV PITTSBURGH,DEPT BIOL SCI,PITTSBURGH,PA 15260

来源：

BRAIN RESEARCH | 1979年 / 170卷 / 02期

关键词：

depolarization; dopamine synthesis; striatum; synaptosomes; tyrosine hydroxylase;

D O I：

10.1016/0006-8993(79)90108-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Incubation of striatal synaptosomes under depolarizing conditions (veratridine or KCl) increased the release of dopamine (DA) and produced a small increase in DA synthesis. This was not accompanied by an activation of either soluble or membrane-bound tyrosine hydroxylase, but was associated with a large depletion of synaptosomal DA. Thus, depolarization may increase DA synthesis by reducing the inhibition of tyrosine hydroxylase by end-product. © 1979.

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页码：299 / 312

页数：14

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