BETA-BLOCKADE THERAPY FOR SUPRAVENTRICULAR TACHYARRHYTHMIAS AFTER CORONARY SURGERY - PROPRANOLOL WITHDRAWAL SYNDROME

被引:67
作者
SALAZAR, C
FRISHMAN, W
FRIEDMAN, S
PATEL, J
LIN, YT
OKA, Y
FRATER, RWM
BECKER, RM
机构
[1] MONTEFIORE HOSP & MED CTR,ALBERT EINSTIEN COLL MED HOSP,DEPT SURG,BRONX,NY 10461
[2] MONTEFIORE HOSP & MED CTR,ALBERT EINSTIEN COLL MED HOSP,DEPT CARDIOL,BRONX,NY 10461
[3] MONTEFIORE HOSP & MED CTR,ALBERT EINSTIEN COLL MED HOSP,DEPT ANESTHESIOL,BRONX,NY 10461
关键词
D O I
10.1177/000331977903001204
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
A high incidence of cardiac arrhythmias and hypertension has been noted after coronary artery bypass surgery in patients previously treated with oral propranolol. Forty-two patients undergoing coronary bypass surgery had propranolol withdrawn 10 hours before surgery and were randomized into a group treated with propranolol immediately postoperatively, and a nontreatment group. Patients treated with prophylactic propranolol had a significantly lower incidence of postoperative supraventricular arrhythmias compared to patients who received no prophylaxis. All the arrhythmias responded rapidly to I mg of intravenous propranolol therapy, whether it was used as a primary treatment or as a supplement to prophylactic propranolol. The findings suggest that (1) there is a high incidence of supraventricular arrhythmias and sinus tachycardia after coronary artery bypass which might reflect an abrupt propranolol withdrawal, and (2) that perioperative prophylactic or supplementary propranolol therapy will successfully prevent or treat most of these arrhythmias. © 1979, Sage Publications. All rights reserved.
引用
收藏
页码:816 / 819
页数:4
相关论文
共 12 条
  • [1] VENTRICULAR TACHYARRHYTHMIAS FOLLOWING SURGERY FOR MYOCARDIAL REVASCULARIZATION - FOLLOW-UP-STUDY
    ABEDIN, Z
    SOARES, J
    PHILLIPS, DF
    SHELDON, WC
    [J]. CHEST, 1977, 72 (04) : 426 - 428
  • [2] ANGELINI P, 1974, Progress in Cardiovascular Diseases, V16, P469, DOI 10.1016/0033-0620(74)90007-3
  • [3] BERNSTEIN V, 1978, ANN R COLL PHYS SURG, V11, P33
  • [4] SAFETY AND EFFICACY OF CONTINUED PROPRANOLOL ADMINISTRATION THROUGH CORONARY-BYPASS SURGERY
    BOUDOULAS, H
    SNYDER, GL
    LEWIS, RP
    KATES, RE
    KARAYANNACOS, PE
    VASKO, JS
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1978, 41 (02) : 359 - 359
  • [5] HYPERSENSITIVITY TO ADRENERGIC-STIMULATION AFTER PROPRANOLOL WITHDRAWAL IN NORMAL SUBJECTS
    BOUDOULAS, H
    LEWIS, RP
    KATES, RE
    DALAMANGAS, G
    [J]. ANNALS OF INTERNAL MEDICINE, 1977, 87 (04) : 433 - 436
  • [6] DIAZ RG, 1974, AM HEART J, V88, P257
  • [7] JOHNSSON G, 1976, Clinical Pharmacokinetics, V1, P233
  • [8] KEON W, 1977, ANN THORAC SURG, V23, P257
  • [9] KIRSH M, 1978, ANN THORAC SURG, V25, P177
  • [10] MATLOFF JM, 1968, CIRCULATION S2, V37, P133