ONE-STEP PREPARATION OF 6-PERFLUOROALKYLALKANOATES OF TREHALOSE AND SUCROSE FOR BIOMEDICAL USES

被引：23

作者：

ABOUHILALE, S ^{[1
]}

GREINER, J ^{[1
]}

RIESS, JG ^{[1
]}

机构：

[1] UNIV NICE SOPHIA ANTIPOLIS, CNRS,UNITE RECH ASSOC,CHIM MOLECUL LAB, PARC VALROSE, F-06034 NICE, FRANCE

来源：

CARBOHYDRATE RESEARCH | 1991年 / 212卷

关键词：

D O I：

10.1016/0008-6215(91)84045-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Mitsunobu reaction has been used to obtain 6-polyfluoroalkanoates of alpha,alpha-trehalose and sucrose in yields of approximately 40% and approximately 25%, respectively. 6,6'-Diesters (3-6%) were formed in some reactions and a 6-ester (1.3%) of alpha-D-glucopyranosyl 3,4-anhydro-beta-D-tagatofuranoside in one reaction. The monoesters displayed strong surfactant properties, and reduced considerably the water surface and fluorocarbon/water interfacial tensions. Preliminary results on biocompatibility were encouraging, especially for the 6-esters of alpha,alpha-trehalose.

引用

页码：55 / 64

页数：10

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