SIMPLE INTERFEROMETER FOR EVANESCENT FIELD REFRACTIVE-INDEX SENSING AS A FEASIBILITY STUDY FOR AN IMMUNOSENSOR

被引:19
作者
HEIDEMAN, RG
KOOYMAN, RPH
GREVE, J
ALTENBURG, BSF
机构
[1] University of Twente, Department of Applied Physics, Enschede
来源
APPLIED OPTICS | 1991年 / 30卷 / 12期
关键词
INTERFEROMETER; EVANESCENT FIELD; REFRACTIVE INDEX SENSING; IMMUNOSENSOR; MULTIMODE FIBER;
D O I
10.1364/AO.30.001474
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We describe a fiber optic interferometric refractive index sensor to illustrate that, by using the evanescent field of an optical waveguide, a potentially very sensitive determination of changes in the refractive index on the waveguide surface can be obtained. These changes can, e.g., be the result of immunoreactions. We used a Mach-Zehnder interferometer configuration with a flow-through cuvette in one arm with a decladded multimode glass fiber of 0.6-mm diameter and 2-cm interaction length. The obtained resolution in measuring refractive index changes is 1 x 10(-3). We also developed the theory describing the sensitivity of this sensor using the modal and the geometrical ray description.
引用
收藏
页码:1474 / 1479
页数:6
相关论文
共 17 条
  • [1] ATTRIDGE JW, 1990, BIOSENSORS 90 C SING, P55
  • [2] SKEW RAYS IN OPTICAL FIBERS
    COZANNET, A
    TREHEUX, M
    [J]. APPLIED OPTICS, 1975, 14 (06): : 1345 - 1350
  • [3] WAVE-GUIDES AS CHEMICAL SENSORS
    DESSY, RE
    [J]. ANALYTICAL CHEMISTRY, 1989, 61 (19) : A1079 - +
  • [4] Kooyman R. P. H., 1987, Proceedings of the SPIE - The International Society for Optical Engineering, V798, P290, DOI 10.1117/12.941122
  • [5] SURFACE-PLASMON RESONANCE IMMUNOSENSORS - SENSITIVITY CONSIDERATIONS
    KOOYMAN, RPH
    KOLKMAN, H
    VANGENT, J
    GREVE, J
    [J]. ANALYTICA CHIMICA ACTA, 1988, 213 (1-2) : 35 - 45
  • [6] OUTPUT GRATING COUPLERS ON PLANAR WAVE-GUIDES AS INTEGRATED OPTICAL CHEMICAL SENSORS
    LUKOSZ, W
    NELLEN, PM
    STAMM, C
    WEISS, P
    [J]. SENSORS AND ACTUATORS B-CHEMICAL, 1990, 1 (1-6) : 585 - 588
  • [7] EXTRAPOLATION OF SNELLS LAW TO OPTICAL FIBERS
    MARCATILI, EA
    [J]. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA, 1973, 63 (11) : 1372 - 1373
  • [8] INTEGRATED OPTICAL INPUT GRATING COUPLERS AS BIOCHEMICAL SENSORS
    NELLEN, PM
    TIEFENTHALER, K
    LUKOSZ, W
    [J]. SENSORS AND ACTUATORS, 1988, 15 (03): : 285 - 295
  • [9] NELLEN PM, 1990, BIOSENSORS 90 C SING, P55
  • [10] NIJLANDER C, 1985, J PHYS E, V18, P736