COMMERCIAL LEVELS OF CHYMOSIN PRODUCTION BY ASPERGILLUS

被引：112

作者：

DUNNCOLEMAN, NS

BLOEBAUM, P

BERKA, RM

BODIE, E

ROBINSON, N

ARMSTRONG, G

WARD, M

PRZETAK, M

CARTER, GL

LACOST, R

WILSON, LJ

KODAMA, KH

BALIU, EF

BOWER, B

LAMSA, M

HEINSOHN, H

机构：

[1] Genencor International Inc., South San Francisco, CA, 94080

来源：

BIO-TECHNOLOGY | 1991年 / 9卷 / 10期

关键词：

D O I：

10.1038/nbt1091-976

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have increased the production of bovine chymosin in Aspergillus niger var. awamori to more than one gram per liter of secreted authenitic enzyme by combining a mutagenesis protocol with a novel robotic screening program. Analysis of the superior chymosin producing strains indicated that they have enhanced capabilities to secrete extracellular proteins.

引用

页码：976 / 981

页数：6

共 25 条

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