MECHANOGENETIC REGULATION OF TRANSCRIPTION

被引：27

作者：

ERDOS, T

BUTLERBROWNE, GS

RAPPAPORT, L

机构：

[1] HOP LARIBOISIERE, INSERM, U127, 41 BD CHAPELLE, F-75475 PARIS 10, FRANCE

[2] CNRS, ENZYMOL LAB, F-91198 GIF SUR YVETTE, FRANCE

[3] FAC MED PARIS, CNRS, UA 1188, F-75006 PARIS, FRANCE

来源：

BIOCHIMIE | 1991年 / 73卷 / 09期

关键词：

MECHANOGENETIC CONTROL; MUSCLE HYPERTROPHY; STRETCH; BACTERIAL OSMOREGULATION; GEOTROPISM;

D O I：

10.1016/0300-9084(91)90007-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In many biological systems mechanical forces regulate gene expression: in bacteria changes in turgor pressure cause a deformation of the membrane and induce the expression of osmoregulatory genes; in plants gravity regulates cell growth ('geotropism'); in mammals stretching a muscle induces hypertrophy which is accompanied by qualitative changes in protein synthesis. Consequently, the term 'mechanogenetic control' seems to be a suitable common name for all these processes. The mechanism by which mechanical factors modulate transcriptional activity is still unknown. The purpose of this review is to bring together data from different fields in order to obtain a better understanding of the mechanogenetic control of cell growth.

引用

页码：1219 / 1231

页数：13

共 142 条

[1]

ADAMSON ED, 1987, DEVELOPMENT, V99, P449

[2]

AIBA H, 1989, J BIOL CHEM, V264, P8563

[3] PHOSPHORYLATION OF A BACTERIAL ACTIVATOR PROTEIN, OMPR, BY A PROTEIN-KINASE, ENVZ, RESULTS IN STIMULATION OF ITS DNA-BINDING ABILITY [J].