15 YEARS EXPERIENCE WITH RENAL-TRANSPLANTATION IN SYSTEMIC AMYLOIDOSIS

被引:61
作者
HARTMANN, A
HOLDAAS, H
FAUCHALD, P
NORDAL, KP
BERG, KJ
TALSETH, T
LEIVESTAD, T
BREKKE, IB
FLATMARK, A
机构
[1] Department of Internal Medicine, The National Hospital, Oslo 1
[2] Institute of Transplantation Immunology, The National Hospital, Oslo 1
[3] Department of Surgery, The National Hospital, Olso 1
关键词
AMYLOIDOSIS; KIDNEY TRANSPLANTATION; SYSTEMIC AMYLOIDOSIS;
D O I
10.1007/BF00337183
中图分类号
R61 [外科手术学];
学科分类号
摘要
At our center 62 renal transplantations (31 living donor and 31 cadaveric donor grafts) have been performed in 58 patients with amyloid renal disease since 1974. The amyloidosis was secondary to rheumatic disease in 74 % of the patients. Predialytic transplantation was performed in 28% of the patients. Mean follow-up time was 5.1 years (0.3-14.5 years). One-year actuarial patient survival was 79%, decreasing to 65% after 5 years. First graft survival was 74 % at 1 year and 62 % at 5 years. Patient death with a functioning graft caused 16 out of 25 graft losses. Infections caused 11 out of 18 deaths (61 %), more than half of them within 3 months. Renal transplant amyloid was diagnosed in about 10% of the cases (6/62); however, only about 3 % of the grafts (2/62) were lost. These long-term results encourage transplantation in amyloid renal end-stage disease.
引用
收藏
页码:15 / 18
页数:4
相关论文
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