COINFECTION OF HEPATITIS-C VIRUS IN PATIENTS WITH CHRONIC HEPATITIS-B INFECTION

被引：115

作者：

SATO, S ^{[1
]}

FUJIYAMA, S ^{[1
]}

TANAKA, M ^{[1
]}

YAMASAKI, K ^{[1
]}

KURAMOTO, I ^{[1
]}

KAWANO, S ^{[1
]}

SATO, T ^{[1
]}

MIZUNO, K ^{[1
]}

NONAKA, S ^{[1
]}

机构：

[1] CHEMOSERO THERAPEUT RES INST,KUMAMOTO,JAPAN

来源：

JOURNAL OF HEPATOLOGY | 1994年 / 21卷 / 02期

关键词：

ENZYME-LINKED IMMUNOSORBENT ASSAY; IGA ANTI-HCV; POLYMERASE CHAIN REACTION;

D O I：

10.1016/S0168-8278(05)80389-7

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Enzyme-linked immunosorbent assays for detecting antibodies against hepatitis C virus and the polymerase chain reaction were tested in 82 chronic hepatitis B surface antigen carriers for their accuracy in diagnosing patients coinfected with hepatitis B and C viruses. To clarify the role of each virus in chronic hepatitis, serologic assays against hepatitis B virus were also tested. Thirteen (14.9%), 14 (17.1%) and 15 (18.3%) patients were anti-HCV positive using C100 (HCV1), JCC, and a second generation test (HCV2), respectively. HCV RNA was detected by polymerase chain reaction in 9 of 18 anti-HCV positive cases. Although HCV1 assays were not sufficient, either the JCC or HCV2 assay detected all polymerase chain reaction-positive cases. Fifteen of 18 specimens that were positive in at least one of the three ELISA were seronegative for the hepatitis B e antigen. As judged by HBV DNA polymerase activity, titers of hepatitis B surface antigen and immunoglobulin A antibody against hepatitis B core antigen (IgA anti-HBc), activity of hepatitis B virus replication and immune response against hepatitis B virus in patients with coinfection was decreased to the level of hepatitis B virus asymptomatic carriers. These results show that hepatitis C virus appears to be the primary cause of active hepatitis in most patients with hepatitis B and hepatitis C virus coinfection. (C) Journal of Hepatology.

引用

页码：159 / 166

页数：8

共 35 条

[1] SERODIAGNOSIS OF HEPATITIS-C VIRUS (HCV) INFECTION WITH AN HCV CORE PROTEIN MOLECULARLY EXPRESSED BY A RECOMBINANT BACULOVIRUS [J].