SEROTONIN DEPLETION BY P-CHLOROPHENYLALANINE DECREASES VIP MESSENGER-RNA IN THE SUPRACHIASMATIC NUCLEUS

被引：19

作者：

KAWAKAMI, F

OKAMURA, H

INATOMI, T

TAMADA, Y

NAKAJIMA, T

IBATA, Y

机构：

[1] KYOTO PREFECTURAL UNIV MED,DEPT ANAT,KAMIKYO KU,KYOTO 602,JAPAN

[2] KYOTO PREFECTURAL UNIV MED,DEPT OPHTHALMOL,KAMIKYO KU,KYOTO 602,JAPAN

[3] KYOTO PREFECTURAL UNIV MED,DEPT PSYCHIAT,KAMIKYO KU,KYOTO 602,JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 174卷 / 01期

关键词：

SEROTONIN; VASOACTIVE INTESTINAL PEPTIDE MESSENGER-RNA; SUPRACHIASMATIC NUCLEUS;

D O I：

10.1016/0304-3940(94)90124-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of serotonergic inputs on the levels of vasoactive intestinal peptide (VIP) mRNA in the rat suprachiasmatic nucleus (SCN). was examined by in situ hybridization combined with morphometrical analysis. Depletion of serotonin by p-chlorophenylalanine methyl ester (300 mg/kg i.p. daily for 3 days) caused a marked decrease in VIP mRNA signal levels in the ventrolateral part of the SCN. This finding suggests that serotonergic input controls VIP production at the mRNA level.

引用

收藏

页码：81 / 84

页数：4

相关论文

共 31 条

[1]

AJIKA K, 1978, J ANAT, V127, P563

[2] IMAGING PLATE ILLUMINATES MANY FIELDS [J].

AMEMIYA, Y ;

MIYAHARA, J .

NATURE, 1988, 336 (6194) :89-90

[3] AUTORADIOGRAPHIC ANALYSIS OF DIFFERENTIAL ASCENDING PROJECTIONS OF DORSAL AND MEDIAN RAPHE NUCLEI IN RAT [J].

AZMITIA, EC ;

SEGAL, M .

JOURNAL OF COMPARATIVE NEUROLOGY, 1978, 179 (03) :641-667

[4] VIP NEURONS AS PRIME SYNAPTIC TARGETS FOR SEROTONIN AFFERENTS IN RAT SUPRACHIASMATIC NUCLEUS - A COMBINED AUTORADIOGRAPHIC AND IMMUNOCYTOCHEMICAL STUDY [J].

BOSLER, O ;

BEAUDET, A .

JOURNAL OF NEUROCYTOLOGY, 1985, 14 (05) :749-763

[5]

FUXE K, 1965, ACTA PHYSIOL SCAND, VS 64, P37

[6] EFFECTS OF PARACHLOROPHENYLALANINE AND 5,6-DIHYDROXYTRYPTAMINE ON THE FREE-RUNNING RHYTHMS OF LOCOMOTOR-ACTIVITY AND PLASMA-CORTICOSTERONE IN THE RAT EXPOSED TO CONTINUOUS LIGHT [J].

HONMA, KI ;

WATANABE, K ;

HIROSHIGE, T .

BRAIN RESEARCH, 1979, 169 (03) :531-544

[7] VASOACTIVE INTESTINAL PEPTIDE (VIP)-LIKE IMMUNOREACTIVE NEURONS LOCATED IN THE RAT SUPRACHIASMATIC NUCLEUS RECEIVE A DIRECT RETINAL PROJECTION [J].

IBATA, Y ;

TAKAHASHI, Y ;

OKAMURA, H ;

KAWAKAMI, F ;

TERUBAYASHI, H ;

KUBO, T ;

YANAIHARA, N .

NEUROSCIENCE LETTERS, 1989, 97 (1-2) :1-5

[8] PERSISTENCE OF CIRCADIAN RHYTHMICITY IN A MAMMALIAN HYPOTHALAMIC ISLAND CONTAINING THE SUPRACHIASMATIC NUCLEUS [J].

INOUYE, ST ;

KAWAMURA, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (11) :5962-5966

[9] THE INFLUENCE OF SEROTONERGIC INPUTS ON PEPTIDE NEURONS IN THE RAT SUPRACHIASMATIC NUCLEUS - AN IMMUNOCYTOCHEMICAL STUDY [J].

KAWAKAMI, F ;

OKAMURA, H ;

FUKUI, K ;

YANAIHARA, C ;

YANAIHARA, N ;

NAKAJIMA, T ;

IBATA, Y .

NEUROSCIENCE LETTERS, 1985, 61 (03) :273-277

[10]

KAWAKAMI F, 1986, BIOMED RES-TOKYO, V7, P79

← 1 2 3 4 →