Transvaginal estriol administration in postmenopausal women: A double blind comparative study of two different doses

被引：19

作者：

Bottiglione, F

Volpe, A

Esposito, G

DeAloysio, D

机构：

[1] ANGELINI PHARMACEUT DIV, ANGELINI MED RES, I-00181 ROME, ITALY

[2] UNIV BOLOGNA, SCH MED, DEPT OBSTET & GYNAECOL, BOLOGNA, ITALY

[3] UNIV CAGLIARI, SCH MED, CHAIR GYNAECOL ONCOL, CAGLIARI, ITALY

来源：

MATURITAS | 1995年 / 22卷 / 03期

关键词：

estriol; vaginal administration; menopause;

D O I：

10.1016/0378-5122(95)00943-F

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

A group of 72 postmenopausal women were treated for 4 weeks with vaginal suppositories containing 0.5 or 1.0 mg of estriol. The two different doses achieved an identical significant improvement of urogenital symptoms, while a dose-related effect seen to be on climacteric complaints, according to a good absorption of estriol by the vaginal epithelium. Minimal side effects were observed and the safety of vaginal estriol treatment could advise further study about the effect of this kind of treatment on the climacteric syndrome.

引用

页码：227 / 232

页数：6

共 24 条

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BERGINK EW, 1980, ACTA ENDOCRINOL-COP, V94, P9

[2]

Bianco V, 1991, Ann Ostet Ginecol Med Perinat, V112, P54

[3] VITAMIN-E AND CLIMACTERIC SYNDROME - FAILURE OF EFFECTIVE CONTROL AS MEASURED BY MENOPAUSAL INDEX [J].