EXCRETION OF CYCLOHEXYLAMINE IN SUBJECTS INGESTING SODIUM CYCLAMATE

Eleven subjects ingesting sodium cyclamate (CYC) daily (1 or 3 g) all excreted cyclohexylamine (CHA) in urine and feces (0.04-154 mg/day). Although excretion of CYC became essentially maximal within 1 week after the start of ingestion of CYC, that of CHA did not reach an essentially constant value until the second week of ingestion of CYC, CYC ingested was not fully recovered as CYC and CHA in urine and feces. Excretion of CHA correlated with constipation frequency (R = 0.85), but bowel habits and fecal consistency were not altered by ingestion of CYC. Incubation of CYC with fresh feces showed that CYC was not converted anaerobically to metabolites. It is concluded that CYC ingested over a prolonged period cannot be fully recovered in the urine and feces, that conversion of CYC to CHA or other metabolities does not occur in feces, and that the excretion rate of CHA is characteristic for each subject and is in some manner related to frequency of constipation. © 1969.