OCCURRENCE OF NEWLY SYNTHESIZED MONOAMINE OXIDASE IN SUBCELLULAR FRACTIONS OF RAT LIVER

被引：16

作者：

ERWIN, VG

SIMON, RJ

机构：

[1] School of Pharmacy, University of Colorado, Boulder, Colorado

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 08期

关键词：

Chloramphenicol effect–monoamine oxidase synthesis; Emetine effect–monoatnine oxidase synthesis; Fluorometry–analysis; Inhibition; monoamine oxidase–activity return rate; Monoamine oxidase; newly synthesized–rat liver; UV spectrophotometry–analysis;

D O I：

10.1002/jps.2600580834

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The rates of return of monoamine oxidase activity in rat liver mitochondrial and microsomal fractions following inhibition by pargyline or iproniazid were investigated. When these irreversible inhibitors were administered at dosages which produced 100% inhibition, the rate of return of enzyme activity was found to be more rapid in the microsomal fractions than in the mitochondrial fractions. In addition, it was observed that emetine or chloramphenicol inhibited the synthesis of monoamine oxidase but inhibition was not noted until 48 hr. after administration of these compounds. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1033 / &

共 14 条

[1]

ARNAIZ GRD, 1962, J NEUROCHEM, V9, P503

[2] ON SITE OF SYNTHESIS OF MITOCHONDRIAL PROTEIN OF NERVE ENDINGS [J].