RADIATION-INDUCED HYPER-PROLACTINEMIA IN A TREATED ACROMEGALIC

被引：18

作者：

SHALET, SM

MACFARLANE, IA

BEARDWELL, CG

机构：

[1] Christie Hospital, Holt Radium Institute, Manchester

来源：

CLINICAL ENDOCRINOLOGY | 1979年 / 11卷 / 02期

关键词：

D O I：

10.1111/j.1365-2265.1979.tb03062.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 31‐year‐old acromegalic was normoprolactinaemic after partial removal of her pituitary tumour. The post‐operative external pituitary irradiation lowered the mean growth hormone (GH) level from 75 mU/1 to less than 1 mU/1 within 2 years. However, at the same time hyperprolactinaemia developed. These changes in the GH and prolactin levels were confirmed 3 and 4 years after irradiation. The cause of the hyperprolactinaemia was radiation‐induced hypothalamic damage. Therefore it is suggested that similar damage may occur in patients receiving external pituitary irradiation for‘prolactinomas’and that this mechanism may contribute to the persistent hyperprolactinaemia observed in such patients. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：169 / 171

页数：3

共 5 条

[1] MANAGEMENT OF HYPERPROLACTINEMIC AMENORRHEA/A
FRANKS, S
JACOBS, HS
HULL, MGR
STEELE, SJ
NABARRO, JDN
[J]. BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1977, 84 (04): : 241 - 253
[2] GOMEZ F, 1977, AM J MED, V62, P648, DOI 10.1016/0002-9343(77)90866-X
[3] PROLACTIN AND AMENORRHEA
JACOBS, HS
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1976, 295 (17) : 954 - 956
[4] HYPOPITUITARISM AFTER EXTRACRANIAL IRRADIATION - EVIDENCE FOR HYPOTHALAMIC ORIGIN
LARKINS, RG
MARTIN, FIR
[J]. BRITISH MEDICAL JOURNAL, 1973, 1 (5846) : 152 - 153
[5] SHALET SM, J PEDIATRICS

← 1 →