EFFECTS OF GONADECTOMY AND HORMONE REPLACEMENT ON BRAIN MONO-AMINE SYNTHESIS IN MALE RATS

被引：37

作者：

ENGEL, J ^{[1
]}

AHLENIUS, S ^{[1
]}

ALMGREN, O ^{[1
]}

CARLSSON, A ^{[1
]}

LARSSON, K ^{[1
]}

SODERSTEN, P ^{[1
]}

机构：

[1] UNIV GOTHENBURG,DEPT PSYCHOL,S-40033 GOTHENBURG 33,SWEDEN

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 10卷 / 01期

关键词：

Castration; Catecholamine synthesis; Central nervous system; Serotonin synthesis; Testosterone;

D O I：

10.1016/0091-3057(79)90181-3

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The synthesis of catecholamines and serotonin in the brains of castrated male rats was analyzed at either various times after castration or at various ages. It was found that (a) castration of rats at 50 days or later causes an increase in brain monoamine synthesis, and (b) this phenomenon was not observed until 20 days after castration. The increase in brain monoamine synthesis following castration was counteracted by treatment with testosterone, thus relating the biochemical consequences of castration with changed hormonal conditions of the animal. It is suggested that testosterone exerts an inhibitory influence on monoamine synthesis. © 1979.

引用

页码：149 / 154

页数：6

共 40 条

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