NEUROMUSCULAR EFFECTS OF ISOFLURANE IN PATIENTS WITH MYASTHENIA-GRAVIS

被引：32

作者：

NILSSON, E ^{[1
]}

MULLER, K ^{[1
]}

机构：

[1] UNIV HELSINKI,CENT HOSP,DEPT NEUROL,SF-00290 HELSINKI 29,FINLAND

来源：

ACTA ANAESTHESIOLOGICA SCANDINAVICA | 1990年 / 34卷 / 02期

关键词：

Anesthesia: isoflurane; HLA antigen; monitoring; myasthenia gravis; nerve stimulator; neuromuscular transmission: nerve stimulator; train‐of‐four;

D O I：

10.1111/j.1399-6576.1990.tb03056.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Seventeen myasthenia gravis and seven control patients were studied mechano (MMG)‐ and electromyographically (EMG) during isoflurane/oxygen/air anaesthesia. In myasthenic patients the mean train‐of‐four ratio and neuromuscular block (by MMG) during 1.9 MAC isoflurane anaesthesia were 55 ± 9% and 46 ± 12%, respectively. The correlation between simultaneous MMG and EMG measurements was excellent (r2=0.933, P<0.001). The occurrence of HLA‐B8 together with acetylcholine receptor antibodies seems to predispose myasthenic patients to a neuromuscular depression produced by isoflurane. Our current and prior results show that isoflurane possesses approximately twice as strong a neuromuscular blocking effect as halothane in myasthenic patients. © 1990 Acta Anaesthesiologica Scandinavica Fonden

引用

页码：126 / 131

页数：6

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