INVESTIGATION OF THE CHIRAL RECOGNITION BY BRUSH-TYPE PHASES IN LIQUID-CHROMATOGRAPHY USING CRYSTAL-STRUCTURE ANALYSES OF DIASTEREOMERIC 1-1 COMPLEXES OF A PI-DONOR AND A PI-ACCEPTOR DERIVATIVE OF LEUCINE

被引：10

作者：

DAPPEN, R

RIHS, G

MAYER, CW

机构：

[1] CIBA GEIGY AG,DEPT PHYS,CH-4002 BASEL,SWITZERLAND

[2] CIBA GEIGY AG,CENT RES LAB,CH-4002 BASEL,SWITZERLAND

来源：

CHIRALITY | 1990年 / 2卷 / 03期

关键词：

3,5‐dinitrobenzoyl group; chiral recognition mechanism; chiral stationary phase;

D O I：

10.1002/chir.530020310

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(R,S)‐N‐Acetyl‐leucine‐2‐naphthylamide can be resolved into its enantiomers on a (S)‐DNBLeucine chiral stationary phase. The mechanism of this separation was investigated using as model complexes the 1:1 S,S‐ and the 1:1 R,S‐cocrystals of the above naphthylamide and N‐3,5‐dinitrobenzoylleucinemethylamide, a soluble analogue of the stationary phase. The observed enantiomeric elution order can be rationalized from their X‐ray data. Copyright © 1990 Wiley‐Liss, Inc.

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页码：185 / 189

页数：5

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