SAFETY AND EFFICACY OF LONG-TERM TOCOLYSIS WITH INDOMETHACIN

被引：38

作者：

GERSON, A ^{[1
]}

ABBASI, S ^{[1
]}

JOHNSON, A ^{[1
]}

KALCHBRENNER, M ^{[1
]}

ASHMEAD, G ^{[1
]}

BOLOGNESE, R ^{[1
]}

机构：

[1] PENN HOSP,DEPT OBSTET & GYNECOL,PERINATOL SECT,PHILADELPHIA,PA 19107

来源：

AMERICAN JOURNAL OF PERINATOLOGY | 1990年 / 7卷 / 01期

关键词：

D O I：

10.1055/s-2007-999450

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Indomethacin was utilized in 24 pregnancies (31 exposed fetuses) in preterm labor who labored despite intravenous tocolysis. The mean gestational age at the start of indomethacin therapy was 25.1 weeks (±4.4), mean duration of indomethacin therapy was 43.9 days (±31.4), mean gestational age at delivery 33.1 weeks (±3.7). Neonatal follow-up revealed the same incidence of complications in these indomethacin-exposed infants, when they were compared with all other infants born in the same time period and exposed to intravenous tocolytics only when matched for gestational age at delivery. © 1990, by Thieme Medical Publishers, Inc. All rights reserved.

引用

页码：71 / 74

页数：4

共 12 条

[1] Huszar G., Naftolin F., The myometrium and uterine cervix in normal and preterm labor, N Engl J Med, 311, (1984)
[2] Zuckerman H., Reiss U., Rubinstein I., Et al., Inhibition of human premature labor by indomethacin, Obstet Gynecol, 44, (1974)
[3] Wiquvist N., Lundstrum V., Green K., Premature labor and indomethacin, Prostaglandins, 10, (1975)
[4] Areilla R.A., Thilenius O.G., Ranniger K., Congestive heart failure from suspected ductal closure in utero, J Pediatr, 75, (1969)
[5] Manchester D., Margolis H.S., Sheldon R.E., Possible association between maternal indomethacin therapy and primary pulmonary hyptertension of the newborn, Am J Obstet Gynecol, 126, (1976)
[6] Itskovitz J., Abramovici H., Brandes J., Oligohydramnion, meconium and perinatal death concurrent with indomethacin treatment in human pregnancy, J Reprod Med, 24, (1980)
[7] Niebyl J.R., Drugs for inhibition of premature labor, Clin Pharmacol, 6, (1979)
[8] Dudley D.K.L., Hardie M.J., Fetal and neonatal effects of indomethacin used as a tocolytic agent, Am J Obstet Gynecol, 151, (1985)
[9] Niebyl J.R., Blake D., White R.D., Et al., The inhibition of premature labor with indomethacin, Am J Obstet Gynecol, 136, (1980)
[10] Steer C.M., Petrie R.H., A comparison of magnesium sulfate and alcohol for the prevention of premature labor, Am J Obstet Gynecol, 129, (1977)

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