SOLID PHASE-NUCLEOTIDE LINKS CLEAVABLE BY MILD ACID TREATMENTS - PHOSPHORAMIDATES, PHOSPHOESTERS AND ETHERS

被引：2

作者：

FELDER, ER

机构：

[1] Pharmaceuticals Division, CIBA-GEIGY Ltd

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 1-3期

关键词：

D O I：

10.1080/07328319108046505

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acid sensitive links between nucleotides and a polystyrene-trialkoxybenzhydryl resin allow for the release of protected oligonucleotide fragments into solution.

引用

页码：495 / 496

页数：2

共 3 条

[1] ESTERIFICATION OF PARTIALLY PROTECTED PEPTIDE-FRAGMENTS WITH RESINS - UTILIZATION OF 2-CHLOROTRITYLCHLORIDE FOR SYNTHESIS OF LEU-15-GASTRIN-I [J].

BARLOS, K ;

GATOS, D ;

KAPOLOS, S ;

PAPAPHOTIU, G ;

SCHAFER, W ;

YAO, WQ .

TETRAHEDRON LETTERS, 1989, 30 (30) :3947-3950

[2] SYNTHESIS OF DNA FRAGMENTS BY THE HYDROXYBENZOTRIAZOLE PHOSPHOTRIESTER APPROACH [J].

MARUGG, JE ;

TROMP, M ;

JHURANI, P ;

HOYNG, CF ;

VANDERMAREL, GA ;

VANBOOM, JH .

TETRAHEDRON, 1984, 40 (01) :73-78

[3] SOLID-PHASE SYNTHESIS OF PROTECTED PEPTIDE-FRAGMENTS USING A TRIALKOXY-DIPHENYL-METHYLESTER RESIN [J].

RINK, H .

TETRAHEDRON LETTERS, 1987, 28 (33) :3787-3790

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