KETOROLAC VERSUS MEPERIDINE AND HYDROXYZINE IN THE TREATMENT OF ACUTE MIGRAINE HEADACHE - A RANDOMIZED, PROSPECTIVE, DOUBLE-BLIND TRIAL

被引：46

作者：

DUARTE, C ^{[1
]}

DUNAWAY, F ^{[1
]}

TURNER, L ^{[1
]}

ALDAG, J ^{[1
]}

FREDERICK, R ^{[1
]}

机构：

[1] UNIV ILLINOIS,COLL MED,DEPT EMERGENCY MED,PEORIA,IL 61656

来源：

ANNALS OF EMERGENCY MEDICINE | 1992年 / 21卷 / 09期

关键词：

HYDROXYZINE; KETOROLAC; MEPERIDINE; MIGRAINE;

D O I：

10.1016/S0196-0644(05)80654-7

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Study objective: To compare the effectiveness of IM ketorolac with that of meperidine and hydroxyzine in the treatment of acute migraine headache. Design: Prospective, randomized, double-blind trial. Setting: Urban emergency department with an annual census of 42,000 patients. Participants: Forty-seven adult patients with migraines enrolled on 50 visits. Interventions: Patients were randomly assigned to receive a single injection of either 60 mg ketorolac (group 1) or 100 mg meperidine and 50 mg hydroxyzine (group 2). Pain assessment was made using both visual-analog and verbal descriptor scales. Results: At 60 minutes, 15 patients (60%) from group 1 (25) and 14 patients (56%) from group 2 (25) reported a great deal of complete relief (P = .77) Sixty-minute mean pain relief scores (3.35 versus 3.37) were different (P = .76). Nine patients (36%) from group 1 and seven patients (28%) from group 2 required additional analgesia (P = .76) Conclusion: Ketorolac is as effective as meperidine and hydroxyzine for the treatment of acute migraine headache.

引用

页码：1116 / 1121

页数：6

共 35 条

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