HUMAN INTERLEUKIN-10 INDUCES NAIVE SURFACE-IMMUNOGLOBULIN D+ (SIGD(+)) B-CELLS TO SECRETE IGG1 AND IGG3

被引：282

作者：

BRIERE, F ^{[1
]}

SERVETDELPRAT, C ^{[1
]}

BRIDON, J ^{[1
]}

SAINTREMY, JM ^{[1
]}

BANCHEREAU, J ^{[1
]}

机构：

[1] UNIV LOUVAIN, EXPTL IMMUNOL UNIT, B-1200 BRUSSELS, BELGIUM

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1994年 / 179卷 / 02期

关键词：

D O I：

10.1084/jem.179.2.757

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During antigen-induced immune responses, human B cells switch isotype from immunoglobulin M (IgM)-IgD to IgG1-4, IgA1-2, or IgE. In the human, no cytokines have yet been demonstrated to act as switch factors for IgG1, IgG2, and IgG3. In this paper, we report that in response to interleukin 10 (IL-10), anti-CD40 activated tonsillar surface IgD(+) (sIgD(+))B cells are induced to secrete large amounts of IgM, IgG1, and IgG3 but neither IgG2 nor IgG4. Cord blood purified B cells and lymphocytes from Hyper-IgM patients also produced IgG1 and IgG3 after culture with anti-CD40 and IL-10. In contrast, sIgD(-) isotype-committed B cells produce IgG1, IgG2, and IgG3 when activated through CD40 in the presence of IL-10. Thus, in addition to its growth-promoting and differentiating activities on human B cells, IL-10 may represent a switch factor for IgG1 and IgG3.

引用

页码：757 / 762

页数：6

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