COMPARATIVE MAPPING REVEALS EXTENSIVE LINKAGE CONSERVATION - BUT WITH GENE ORDER REARRANGEMENTS - BETWEEN THE PIG AND THE HUMAN GENOMES

被引：93

作者：

JOHANSSON, M

ELLEGREN, H

ANDERSSON, L

机构：

[1] Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala S-751 24

来源：

GENOMICS | 1995年 / 25卷 / 03期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1016/0888-7543(95)80011-A

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A porcine comparative map based on 83 coding loci was constructed. Comparisons to the human and mouse genetic maps revealed linkage conservation between humans and pigs more extensive than that between any of these and the mouse. The average lengths of conserved chromosome segments between pig and human and between pig and mouse were estimated at 37 and 21 cM, respectively. Rearrangements of gene orders within homologous chromosome segments were found to be common among these distantly related mammals. The development of a comparative map is an advance in pig genome analysis and contributes to the dissection of mammalian genome evolution. (C) 1995 Academic Press, Inc.

引用

页码：682 / 690

页数：9

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