REVERSIBLE MODIFICATION OF THE ACID-LABILE 2-HYDROXY-4-METHOXYBENZYL (HMB) AMIDE PROTECTING GROUP - A SIMPLE SCHEME YIELDING BACKBONE SUBSTITUTED FREE PEPTIDES

被引：22

作者：

QUIBELL, M ^{[1
]}

TURNELL, WG ^{[1
]}

JOHNSON, T ^{[1
]}

机构：

[1] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(00)76807-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acetylation of the trifluoroacetic acid labile 2-hydroxy-4-methoxybenzyl (Hmb) amide protecting group (1) gave a dramatic increase in acid stability. This enabled peptides prepared by the Fmoc/t-butyl solid phase strategy to be deprotected and cleaved whilst retaining backbone amide protection. Acid lability was easily restored by piperidine mediated de-O-acetylation.

引用

页码：2237 / 2238

页数：2