ALKYL-BISBIGUANIDES AS INVITRO INHIBITORS OF BACTERIAL-GROWTH AND DENTAL PLAQUE-FORMATION

被引：7

作者：

BAKER, PJ ^{[1
]}

COBURN, RA ^{[1
]}

GENCO, RJ ^{[1
]}

EVANS, RT ^{[1
]}

机构：

[1] SUNY COLL BUFFALO, SCH PHARM, DEPT MED CHEM, BUFFALO, NY 14222 USA

来源：

JOURNAL OF PERIODONTAL RESEARCH | 1979年 / 14卷 / 04期

关键词：

D O I：

10.1111/j.1600-0765.1979.tb00799.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Nine anllogues of chlorhexidine, including Alexidine, in which the p‐chloroophenyl group had bneen replaced by straight or branched alkyl chains were found to be substantive ot saliva coated enamel. These alkyl bisbiguanides were also found to be antimicrobial in a tube dilution assay and tn prevent the formation of plaque in an in vitro plaque assay. Each of these compounds was found to be equal to or greater than chlorhexidine in antimicrobial or plaque inhibition activity against the periodontal organisms, Actinomyces viscosus and A. naeslundii. Against the cariogenic organism, Streptococcus mutans, each of these compounds was active but none had more active than several of the other analogues. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：352 / 360

页数：9

共 19 条

[1] DENTAL PLAQUE REDUCTION WITH AN ANTIBACTERIAL MOUTH RINSE .1.
BARNES, GP
BHASKAR, SN
BUSH, AG
CARTER, HG
GROSS, A
SCHILDT, NN
[J]. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 1972, 34 (03): : 553 - &
[2] The calculation of the dosage-mortality curve
Bliss, CI
[J]. ANNALS OF APPLIED BIOLOGY, 1935, 22 (01) : 134 - 167
[3] INVITRO ANTIPLAQUE PROPERTIES OF A SERIES OF ALKYL BIS(BIGUANIDES)
COBURN, RA
BAKER, PJ
EVANS, RT
GENCO, RJ
FISCHMAN, SL
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (08) : 828 - 829
[4] CUTLER RA, 1966, SOAP CHEM SPECIA FEB, P101
[5] CUTLER RA, 1966, SOAP CHEM SPECIA FEB, P45
[6] 1-6-DI-4'-CHLOROPHENYLDIGUANIDOHEXANE (HIBITANE) - LABORATORY INVESTIGATION OF A NEW ANTIBACTERIAL AGENT OF HIGH POTENCY
DAVIES, GE
FRANCIS, J
MARTIN, AR
ROSE, FL
SWAIN, G
[J]. BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1954, 9 (02): : 192 - 196
[7] INVITRO ANTIPLAQUE EFFECTS OF ANTISEPTIC PHENOLS
EVANS, RT
BAKER, PJ
COBURN, RA
FISCHMAN, SL
GENCO, RJ
[J]. JOURNAL OF PERIODONTOLOGY, 1977, 48 (03) : 156 - 162
[8] COMPARISON OF ANTIPLAQUE AGENTS USING AN INVITRO ASSAY REFLECTING ORAL CONDITIONS
EVANS, RT
BAKER, PJ
COBURN, RA
GENCO, RJ
[J]. JOURNAL OF DENTAL RESEARCH, 1977, 56 (06) : 559 - 567
[9] SURFACE-CHEMICAL STUDIES ON CHLORHEXIDINE AND RELATED COMPOUNDS .2. INTERACTIONS WITH MONOMOLECULAR-FILM SYSTEMS
FISHER, RG
QUINTANA, RP
[J]. JOURNAL OF DENTAL RESEARCH, 1975, 54 (01) : 25 - 31
[10] RELATIONSHIP BETWEEN PLAQUE-INHIBITING EFFECT AND RETENTION OF CHLORHEXIDINE IN HUMAN ORAL CAVITY
GJERMO, P
BONESVOLL, P
ROLLA, G
[J]. ARCHIVES OF ORAL BIOLOGY, 1974, 19 (11) : 1031 - 1034

← 1 2 →