COMPARISON OF EFFECTS ON CEREBRAL BLOOD-FLOW OF RAPID REDUCTION IN SYSTEMIC ARTERIAL-PRESSURE BY DIAZOXIDE AND LABETALOL IN HYPERTENSIVE PATIENTS - PRELIMINARY FINDINGS

1 Diazoxide 300 mg and labetalol 150 mg were each injected intravenously on separate occasions into five patients with essentail hypertension. The reduction in BP caused by labetalol was slightly greater than that produced by diazoxide. 2 In contrast the reduction in cerebral blood flow (CBF) by labetalol was not statistically significant, whereas diazoxide gave a greater and statistically significant reduction in CBF. 3 These observations suggest that labetalol may have an advantage over diazoxide for the rapid reduction in BP. 1979 The British Pharmacological Society