PYRIMIDONES-1 - SYNTHESIS OF SOME 1-SUBSTITUTED-5-ARYL AND (4,5-DIARYL)-2(1H)PYRIMIDONES

被引：12

作者：

COPPOLA, GM

FRASER, JD

HARDTMANN, GE

HUEGI, BS

KATHAWALA, FG

机构：

[1] Chemistry Research Department, Pharmaceutical Division, Sandoz, Inc., East Hanover, New Jersey

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1979年 / 16卷 / 03期

关键词：

D O I：

10.1002/jhet.5570160329

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 1-substituted-5-aryl-2(1H)pyrimidones was prepared by a method involving condensation of an appropriate N-substituted urea with 2-aryl-3-(dimethylamino)-acroleins or 2-arylmalondialdehydes. On biological investigation, several compounds exhibited some antiinflammatory activity.

引用

页码：545 / 554

页数：10

共 5 条

[1] SYNTHESIS AND REACTIONS OF 2-ARYL-3-(DIMETHYLAMINO)ACROLEINS
COPPOLA, GM
HARDTMANN, GE
HUEGI, BS
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1974, 11 (01) : 51 - 56
[2] DARSTELLUNG UMSETZUNGEN + EIGENSCHAFTEN VON ENAMIDEN .7. MITT UBER UNTERSUCHUNGEN ACYL-ENAMIN
EIDEN, F
NAGAR, BS
[J]. ARCHIV DER PHARMAZIE UND BERICHTE DER DEUTSCHEN PHARMAZEUTISCHEN GESSELSCHAFT, 1964, 297 (06): : 367 - &
[3] SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME 1-ALKYL-4-PHENYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONES
HARDTMAN.GE
HUEGI, B
KOLETAR, G
KROIN, S
OTT, H
PERRINE, JW
TAKESUE, EI
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (06) : 636 - 639
[4] 1,3-DIHYDRO-1-METHYL-5,6- (AND 5,7-) DIARYL-2H-1,4-DIAZEPIN-2-ONES
HOFMANN, CM
SAFIR, SR
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (05) : 914 - &
[5] Oxymethylene aldehyde. I. Oxymethylene-phenylacetaldehyde
Rupe, H
Knup, E
[J]. HELVETICA CHIMICA ACTA, 1927, 10 : 299 - 309

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