CONTRIBUTION OF SPLANCHNIC AND PERIPHERAL VASCULAR TISSUES TO THE DISPOSAL OF ANGIOTENSIN-II AND TO REGIONAL CONVERSION RATES OF ANGIOTENSIN-I - A PILOT-STUDY IN HUMANS

被引:11
作者
GASIC, S [1 ]
KLEINBLOESEM, CH [1 ]
HEINZ, G [1 ]
WALDHAUSL, W [1 ]
机构
[1] F HOFFMANN LA ROCHE & CO LTD,RES DEPT,CH-4002 BASEL,SWITZERLAND
关键词
PERIPHERAL VASCULAR ANGIOTENSIN CONVERSION; ANGIOTENSIN DISPOSAL;
D O I
10.1097/00005344-199104000-00014
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The present study investigates angiotensin-II (A-II) balance across the splanchnic vascular bed and leg vascular tissues in humans, at baseline conditions and following a systemically ineffective femoral arterial angiotensin-I (A-I) infusion, both before and during inhibition of angiotensin-converting enzyme (ACE) with enalaprilat. In six healthy men, net regional A-II balance was calculated from the transfemoral or transsplanchnic arteriovenous differences in plasma concentrations and the corresponding regional plasma flow. Systemic and splanchnic hemodynamics remained unchanged throughout the trial, indicating an absence of major hemodynamic effects during A-I infusion or concomitant ACE inhibition. In contrast, regional leg plasma flow significantly decreased following A-I infusion (165.2 +/- 15.7 vs. 304.7 +/- 43.7; p < 0.01) and again gradually returned to about baseline values after ACE inhibition. Baseline net transfemoral A-II balance was equilibrated at slight formation rates in four subjects and at minimal extraction rates in two of the six subjects. Following A-I infusion, a shift toward net femoral A-II formation (average increase 2,774% above baseline) was observed in all subjects (p < 0.01). After concomitant ACE inhibition, femoral A-II balance again returned to baseline levels. Across the splanchnic vascular bed a net baseline A-II extraction was observed in all subjects. Following A-I infusion an average increase by 285% (p < 0.05) in splanchnic A-II extraction was observed. During concomitant ACE inhibition splanchnic A-II extraction tended to decrease toward baseline values in four subjects, and remained rather unchanged in two subjects. Results indicate that in humans peripheral and splanchnic vascular tissues contribute to the overall A-II balance. The splanchnic vascular bed counterregulates changes in peripheral A-II formation, thus actively influencing net systemic A-II disposal.
引用
收藏
页码:615 / 620
页数:6
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