AUTO-IMMUNE ALTERATIONS IN THE NEUROHYPOPHYSIS OF RABBITS IMMUNIZED AGAINST VASOPRESSIN

被引：12

作者：

CAU, P ^{[1
]}

ROUGONRAPUZZI, G ^{[1
]}

机构：

[1] CTR IMMUNOL MARSEILLE LUMINY,INSERM,CNRS,F-13288 MARSEILLE 2,FRANCE

来源：

BRAIN RESEARCH | 1979年 / 177卷 / 02期

关键词：

D O I：

10.1016/0006-8993(79)90777-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rabbits immunized against vasopressin developed clinical signs of diabetes insipidus persisting for up to two months after the last boost. Ultrastructural and immunocytochemical studies of the neurohypophysis demonstrated autoimmune alterations: infiltration by immune cells and extracellular deposits of immunoglobulins. No alterations were observed in the hypothalamic nuclei synthesizing vasopressin nor in hormone-target cells of the kidney. Immunization against vasopressin may provide the first example of an autoimmune disease in the hypothalamo-neurohypophysial system. © 1979.

引用

页码：265 / 271

页数：7

共 10 条

[1] ELECTRON MICROSCOPIC STUDIES OF EXPERIMENTAL NEPHRITIS WITH FERRITIN-CONJUGATED ANTIBODY - BASEMENT MEMBRANES AND CISTERNAE OF VISCERAL EPITHELIAL CELLS IN NEPHRITIC RAT GLOMERULI [J].

ANDRES, GA ;

RIFKIND, RA ;

HSU, KC ;

SEEGAL, BC ;

MORGAN, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 1962, 115 (05) :929-&

[2] DEVELOPMENT OF A RADIOIMMUNOASSAY FOR ARGININE-VASOPRESSIN - PRODUCTION OF ANTISERA AND LABELED HORMONE - SEPARATION TECHNIQUES - SPECIFICITY AND SENSITIVITY OF ASSAY IN AQUEOUS-SOLUTION [J].

EDWARDS, CRW ;

KITAU, MJ ;

CHARD, T ;

FORSLING, ML ;

LANDON, J .

JOURNAL OF ENDOCRINOLOGY, 1972, 52 (02) :279-&

[3]

KAMOI K, 1977, ENDOCRINOL JAPON, V24, P239

[4] ULTRASTRUCTURAL LOCALIZATION OF INTRACELLULAR ANTIGEN USING ENZYMELABELED ANTIBODY FRAGMENTS [J].

KRAEHENBUHL, JP ;

DEGRANDI, PB ;

CAMPICHE, MA .

JOURNAL OF CELL BIOLOGY, 1971, 50 (02) :432-+

[5] ULTRASTRUCTURAL STUDY BY IMMUNOPEROXIDASE OF A RAT MEMBRANOUS GLOMERULONEPHRITIS [J].

LALIBERTE, F ;

SAPIN, C ;

DRUET, P ;

BARIETY, J .

JOURNAL OF ULTRASTRUCTURE RESEARCH, 1975, 50 (02) :150-158

[6] IN VIVO AND IN VITRO INACTIVATION OF BIOLOGICAL ACTIVITY OF VASOPRESSIN BY ANTISERUM TO LYSINE VASOPRESSIN [J].

MILLER, M ;

MOSES, AM .

ENDOCRINOLOGY, 1969, 84 (04) :798-+

[7] POSSIBLE RELATIONSHIP BETWEEN AFFINITY OF ARGININE-VASOPRESSIN ANTIBODIES AND DEGREE OF POLYURIA AND POLYDIPSIA IN ACTIVELY IMMUNIZED RABBITS [J].

MORTON, JJ ;

WAITE, MA .

JOURNAL OF ENDOCRINOLOGY, 1972, 54 (03) :523-&

[8]

ROUGONRAPUZZI G, 1977, BIOCHIMIE, V59, P939

[9] RADIOIMMUNOASSAY MEASUREMENT OF ARGININE VASOPRESSIN IN SERUM - DEVELOPMENT AND APPLICATION [J].

SKOWSKY, WR ;

ROSENBLOOM, AA ;

FISHER, DA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1974, 38 (02) :278-287

[10] IMMUNOFLUORESCENCE OF VASOPRESSIN AND OXYTOCIN IN RAT HYPOTHALAMO-NEUROHYPOPHYSEAL SYSTEM [J].

SWAAB, DF ;

POOL, CW ;

NIJVELDT, F .

JOURNAL OF NEURAL TRANSMISSION, 1975, 36 (3-4) :195-215

← 1 →