CRYSTALLIZATION AND PRELIMINARY CRYSTALLOGRAPHIC ANALYSIS OF A TNF-BETA-55 KDA TNF RECEPTOR COMPLEX

被引：21

作者：

DARCY, A

BANNER, DW

JANES, W

WINKLER, FK

LOETSCHER, H

SCHONFELD, HJ

ZULAUF, M

GENTZ, R

LESSLAUER, W

机构：

[1] Department of Pharmaceutical Research-new technology, F. Hoffman-La Roche Ltd.

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1993年 / 229卷 / 02期

关键词：

TNF; RECEPTOR; CYTOKINES; CRYSTALLIZATION;

D O I：

10.1006/jmbi.1993.1055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A complex of tumour necrosis factor-β with the soluble extracellular domain of the human 55 kDa TNF receptor has been crystallized. Crystals of the complex were grown using polyethylene glycol 4000 as the precipitating agent in the presence of β-octyl glucoside. The receptor-ligand complex crystallizes in a cubic space group and diffracts to 2.85 AÅ. © 1993 Academic Press, Inc.

引用

页码：555 / 557

页数：3

共 17 条

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[2]

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[3]

ECK MJ, 1989, J BIOL CHEM, V264, P17595

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