LEUKOCYTE CELL-ADHESION PROTEINS - FROM MOLECULAR DISSECTION TO CLINICAL-APPLICATIONS

被引：7

作者：

GAHMBERG, CG

NORTAMO, P

LI, R

VALMU, L

机构：

[1] Department of Biochemistry, University of Helsinki, Helsinki

来源：

ANNALS OF MEDICINE | 1992年 / 24卷 / 05期

基金：

芬兰科学院;

关键词：

MEMBRANES; LEUKOCYTES; GLYCOPROTEINS; CELL ADHESION;

D O I：

10.3109/07853899209147832

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Leukocyte adhesion is needed for a number of leukocyte functions like immunoglobulin synthesis, T and NK-cell-mediated cytotoxicity, phagocytosis by granulocytes, and cellular accumulation in inflamed tissue. Several cell surface molecules involved in leukocyte-leukocyte and leukocyte-target cell interactions have recently been indentified and characterized. Both the polypeptide and carbohydrate portions are important in leukocyte interactions. It is becoming increasingly apparent that it is possible to interfere with the normal functions of the leukocyte adhesion glycoproteins, and such applications may become important in medicine.

引用

页码：329 / 335

页数：7

共 79 条

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