CYCLIC AMP-DEPENDENT INCREASE OF STEROIDOGENESIS IN BRAIN CORTICAL MINCES

被引：24

作者：

BARBACCIA, ML ^{[1
]}

ROSCETTI, G ^{[1
]}

TRABUCCHI, M ^{[1
]}

AMBROSIO, C ^{[1
]}

MASSOTTI, M ^{[1
]}

机构：

[1] IST SUPER SANITA,PHARMACOL LAB,I-00161 ROME,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 219卷 / 03期

关键词：

STEROIDOGENESIS; CAMP; BRAIN CORTICAL MINCES;

D O I：

10.1016/0014-2999(92)90495-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rat brain cortical minces were incubated with forskolin and dibutyryl-cyclic AMP for 60 and 30 min, respectively. The concentrations of pregnenolone, progesterone and desoxycorticosterone in this preparation were significantly increased by both substances. The results indicate that, in brain tissue, steroidogenesis appears to be regulated by receptor transduction mechanisms that operate through adenylate cyclase.

引用

页码：485 / 486

页数：2

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