NOVEL ALKALOIDS FROM THE SPONGE BATZELLA SP - INHIBITORS OF HIV GP120-HUMAN CD4 BINDING

被引:673
作者
PATIL, AD
KUMAR, NV
KOKKE, WC
BEAN, MF
FREYER, AJ
DEBROSSE, C
MAI, S
TRUNEH, A
FAULKNER, DJ
CARTE, B
BREEN, AL
HERTZBERG, RP
JOHNSON, RK
WESTLEY, JW
POTTS, BCM
机构
[1] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,DEPT ANALYT SCI,KING OF PRUSSIA,PA 19406
[2] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,DEPT PHYS & STRUCT CHEM,KING OF PRUSSIA,PA 19406
[3] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,DEPT CELLULAR BIOCHEM,KING OF PRUSSIA,PA 19406
[4] UNIV CALIF SAN DIEGO,SCRIPPS INST OCEANOG,LA JOLLA,CA 92093
关键词
D O I
10.1021/jo00110a021
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The Caribbean sponge Batzella sp. contains a number of guanidine alkaloids, two of which, batzelladines A (1) and B (2), inhibit the binding of HIVgp-120 to CD4 and are therefore potential inhibitors of HIV. In addition to the known metabolites ptilomycalin A (6), ptilocaulin (7), crambescin A (8), crambescidin 800 (9), and crambescidin 816 (10), Batzella sp. contains five new alkaloids, batzelladines A-E (1-5), the structures of which were elucidated by interpretation of spectral data and chemical degradation.
引用
收藏
页码:1182 / 1188
页数:7
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