SERUM AND SALIVA CORTISOL RELATIONS IN ADOLESCENTS DURING PREGNANCY AND THE EARLY POSTPARTUM PERIOD

被引:7
作者
DORN, LD [1 ]
SUSMAN, EJ [1 ]
机构
[1] PENN STATE UNIV, BIOBEHAV HLTH PROGRAM, UNIV PK, PA 16802 USA
关键词
SALIVA CORTISOL; SERUM CORTISOL; PREGNANCY; ADOLESCENT PREGNANCY;
D O I
10.1016/0006-3223(93)90076-P
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The purpose of this investigation was to examine: (1) relations between serum and saliva cortisol in adolescents in pregnancy and early postpartum and (2) short-term consistency of serum and saliva cortisol across three samples, 20 minutes apart, as well as the long-term consistency from pregnancy to early postpartum. Pregnant adolescents (n = 40), ages 14 to 19 years, were enrolled in this study. Subjects were seen at 20 weeks gestation or earlier (T1), 34-36 weeks gestation (T2), and 2-3 weeks postpartum (T3). Blood samples were drawn at T1 and T3, at 0, 20, and 40 minutes. Saliva samples were collected across the same 40-minute period at T1, T2, and T3. Spearman rho (r(s)) correlation coefficients between serum and saliva ranged from 0.72 to 0.77 (T1), and 0.42 to 0.60 (T3) (p less-than-or-equal-to 0.05). Short-term consistency between serum cortisol samples was 0.86-0.97 at T1 and 0.60-0.82 at T3. Short-term consistency for saliva cortisol samples was 0.70-0.96 at T1, 0.91-0.95 at T2, and 0.64-0.89 at T3. Long-term consistency (T1 to T3) for serum and saliva cortisol was low. Individual differences as well as dramatic changes in the endocrine environment in pregnancy and the early postpartum period may explain the more moderate serum-saliva correlations in the postpartum period.
引用
收藏
页码:226 / 233
页数:8
相关论文
共 42 条
[1]  
BALLARD PL, 1979, GLUCOCORTICOID HORMO, P25
[2]   ISOLATION, CHARACTERIZATION AND RADIOIMMUNOASSAY OF CORTICOSTEROID-BINDING GLOBULIN (CBG) IN HUMAN-SERUM - CLINICAL SIGNIFICANCE AND COMPARISON TO THYROXINE-BINDING GLOBULIN (TBG) [J].
BERNUTZ, C ;
HANSLE, WO ;
HORN, K ;
PICKARDT, CR ;
SCRIBA, PC ;
FINK, E ;
KOLB, H ;
TSCHESCHE, H .
ACTA ENDOCRINOLOGICA, 1979, 92 (02) :370-384
[3]   CORRELATION OF SERUM AND SALIVARY CORTISOL-LEVELS IN PREPUBERTAL SCHOOL-AGED CHILDREN [J].
BOBER, JF ;
WELLER, EB ;
WELLER, RA ;
TAIT, A ;
FRISTAD, MA ;
PRESKORN, SH .
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1988, 27 (06) :748-750
[4]   LONGITUDINAL-STUDY OF FREE CORTISOL INDEX IN PREGNANCY [J].
BRIEN, TG ;
DALRYMPLE, IJ .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1976, 83 (05) :361-367
[5]  
BURKE PM, 1985, AM J PSYCHIAT, V142, P1065
[6]   PAROTID-SALIVA CORTISOL IN NORMAL SUBJECTS - INCREASE DURING PREGNANCY [J].
BUSTAMANTE, B ;
CRABBE, J .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1984, 20 (6A) :1333-1336
[7]   MATERNAL PLASMA ADRENOCORTICOTROPIN AND CORTISOL RELATIONSHIPS THROUGHOUT HUMAN-PREGNANCY [J].
CARR, BR ;
PARKER, CR ;
MADDEN, JD ;
MACDONALD, PC ;
PORTER, JC .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1981, 139 (04) :416-422
[8]  
COSTELLO AJ, 1981, DEV TESTING NIMH DIA
[9]   24-HOUR CORTISOL MEASURES IN ADOLESCENTS WITH MAJOR DEPRESSION - A CONTROLLED-STUDY [J].
DAHL, RE ;
RYAN, ND ;
PUIGANTICH, J ;
NGUYEN, NA ;
ALSHABBOUT, M ;
MEYER, VA ;
PEREL, J .
BIOLOGICAL PSYCHIATRY, 1991, 30 (01) :25-36
[10]   SERUM CBG, FREE AND TOTAL CORTISOL AND CIRCADIAN PATTERNS OF ADRENAL-FUNCTION IN NORMAL-PREGNANCY [J].
DEMEYPONSART, E ;
FOIDART, JM ;
SULON, J ;
SODOYEZ, JC .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1982, 16 (02) :165-169