HISTOLOGIC FEATURE RELIABILITY IN CHILDHOOD NEURAL TUMORS

被引:27
作者
GILLES, FH
SOBEL, EL
LEVITON, A
TAVARE, CJ
HEDLEYWHYTE, ET
BLANK, WF
FULLING, KH
BLAIR, JD
DEMELLO, D
SOTREL, A
ORSINI, EN
ISAACS, H
RORKE, LB
HASHIDA, Y
PRICE, RA
YUNIS, EJ
ZAIAS, BW
BECKER, LE
DAVIS, RL
DELEON, GA
HUFF, D
MESTRE, G
SHAMSZADEH, M
ADELMAN, LS
AVERILL, RD
DEGIROLAMI, U
KLEINMAN, GM
MORRIS, JH
RICHARDSON, EP
SCHOENE, WC
SMITH, TW
SOBEL, RA
KENNEY, C
MORELLI, D
SOBEL, E
机构
[1] CHILDRENS HOSP LOS ANGELES,MED LAB,LOS ANGELES,CA
[2] UNIV SO CALIF,SCH MED,LOS ANGELES,CA
[3] UNIV SO CALIF,SCH MED,DEPT PREVENT MED,LOS ANGELES,CA 90033
[4] CHILDRENS HOSP,BOSTON,MA
[5] MASSACHUSETTS GEN HOSP,BOSTON,MA
[6] BARNES & ST LOUIS CHILDRENS HOSP,ST LOUIS,MO
[7] CARDINAL GLENNON MEM HOSP CHILDREN,ST LOUIS,MO
[8] CHILDRENS HOSP,DENVER,CO
[9] CHILDRENS HOSP PHILADELPHIA,PHILADELPHIA,PA
[10] CHILDRENS HOSP PITTSBURGH,PITTSBURGH,PA
[11] HOSP SICK CHILDREN,TORONTO,ON,CANADA
[12] UNIV SO CALIF,MED CTR,LOS ANGELES,CA
[13] TUFTS UNIV,SCH MED,MEDFORD,MA 02155
[14] UNIV MICHIGAN,SCH MED,ANN ARBOR,MI 48109
[15] UNIV CALIF SAN FRANCISCO,SAN FRANCISCO,CA
[16] UNIV MASSACHUSETTS,SCH MED,AMHERST,MA 01003
[17] HARVARD UNIV,SCH MED,BOSTON,MA
[18] UNIV CONNECTICUT,YALE MED SCH,STORRS,CT 06269
[19] UNIV PENN,SCH MED,PHILADELPHIA,PA 19104
关键词
BRAIN TUMOR; CHILDREN; HISTOLOGY; JACCARD; KAPPA; OBSERVER RELIABILITY;
D O I
10.1097/00005072-199411000-00003
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We studied intraobserver reproducibility in recognizing the presence or absence of 57 histologic features or patterns in a random subset of tumors (822) from the Childhood Brain Tumor Consortium database. The study protocol maximized consistency of the observer. We found that only six histologic features had high (greater than or equal to 0.75) reliability estimates while a large number had intermediate estimates of 0.50-0.74. Supratentorial or infratentorial tumor location sometimes altered reliability. Reliability estimates were unacceptable for certain histologic features often used as diagnostic criteria, descriptors of tumor characteristics, or markers of anaplasia. We hypothesize that low reliability reflects, in part, the need for more specific operational definitions, particularly those with subjective boundaries (e.g. the cellular density constituting the histologic boundary between high and intermediate cell density). Rarity of a feature in the microscopic section (e.g. granular bodies) may also contribute to low reliability. We also show that the kappa statistic, a commonly used measure of reliability, is inappropriate for very common or uncommon histologic features (e.g. features at the extremes of prevalence in the study cases) and we offer a simple empiric method for determining when an alternative measure, the Jaccard statistic, is appropriate.
引用
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页码:559 / 571
页数:13
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