PROPRANOLOL INHIBITS THE INVITRO CONVERSION OF THYROXINE INTO TRIIODOTHYRONINE BY ISOLATED RAT-LIVER PARENCHYMAL-CELLS

被引：36

作者：

VANNOORDEN, CJF ^{[1
]}

WIERSINGA, WM ^{[1
]}

TOUBER, JL ^{[1
]}

机构：

[1] UNIV AMSTERDAM,WILHELMINA GASTHUIS,DEPT MED,DIV ENDOCRINOL,AMSTERDAM,NETHERLANDS

来源：

HORMONE AND METABOLIC RESEARCH | 1979年 / 11卷 / 05期

关键词：

D O I：

10.1055/s-0028-1092740

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A model for the in vitro study of the conversion of thyroxine into triiodothyronine using isolated rat liver parenchymal cells is described. Isolated liver cells (mean protein content 18 mg/ml convert approximately 0.8% of 1.3 μM exogenously added T4 into T3 during thirty minutes incubation. Carbimazole (50 μM) has no effect on the conversion process, whereas propylthiouracil (50 μM) inhibits the conversion. The β-adrenoceptor blocking agent propranolol lowers the conversion ratio when added in concentrations of 580 and 1160 μM, but has no inhibitory effect when 290 μM is added.

引用

页码：366 / 370

页数：5

共 29 条

[1] TRIIODOTHYRONINE AND THYROXINE IN HYPERTHYROIDISM - COMPARISON OF ACUTE CHANGES DURING THERAPY WITH ANTITHYROID AGENTS
ABUID, J
LARSEN, PR
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1974, 54 (01) : 201 - 208
[2] ARMITAGE P, 1971, STATISTICAL METHODS
[3] CONVERSION OF THYROXINE (T4) TO TRIIODOTHYRONINE (T3) IN ATHYREOTIC HUMAN SUBJECTS
BRAVERMAN, LE
INGBAR, SH
STERLING, K
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1970, 49 (05) : 855 - +
[4] EFFECT OF AMIODARONE ON SERUM TRIIODOTHYRONINE, REVERSE TRIIODOTHYRONINE, THYROXINE, AND THYROTROPIN - DRUG INFLUENCING PERIPHERAL METABOLISM OF THYROID-HORMONES
BURGER, A
DINICHERT, D
NICOD, P
JENNY, M
LEMARCHANDBERAUD, T
VALLOTTON, MB
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1976, 58 (02) : 255 - 259
[5] BURGI H, 1976, J CLIN ENDOCR METAB, V43, P1203
[6] BURR WA, 1976, LANCET, V2, P58
[7] CHEUNG MC, 1976, CLIN CHEM, V22, P299
[8] ASSESSMENT OF DAILY PRODUCTION AND SIGNIFICANCE OF THYROIDAL SECRETION OF 3,3',5'-TRIIODOTHYRONINE (REVERSE T3) IN MAN
CHOPRA, IJ
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1976, 58 (01) : 32 - 40
[9] OPPOSITE EFFECTS OF DEXAMETHASONE ON SERUM CONCENTRATIONS OF 3,3',5'-TRIIODOTHYRONINE (REVERSE-T3) AND 3,3',5-TRIIODOTHYRONINE (T3)
CHOPRA, IJ
WILLIAMS, DE
ORGIAZZI, J
SOLOMON, DH
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1975, 41 (05) : 911 - 920
[10] STUDY OF EXTRATHYROIDAL CONVERSION OF THYROXINE (T4) TO 3,3',5-TRIIODOTHYRONINE (T3) INVITRO
CHOPRA, IJ
[J]. ENDOCRINOLOGY, 1977, 101 (02) : 453 - 463

← 1 2 3 →