LACK OF CYTOGENETIC EFFECTS IN MICE OR MUTATIONS IN SALMONELLA RECEIVING SODIUM-FLUORIDE

The effect of fluoride intake on chromosome damage was examined. There was no evidence of increased frequency of chromosomal aberration in bone marrow or testis cells of mice with either 50 ppm fluoride intake over several generations or 100 ppm intake for 6 wk compared to animals drinking distilled water. Fluoride was not mutagenic in a widely used bacterial [Salmonella] mutagenesis assay over a range of 0.1 to as high as 2000 .mu.g fluoride/plate. [Applicability to humans is discussed].