MILD RENAL-FAILURE INDUCED BY SUBCHRONIC EXPOSURE TO MOLYBDENUM - URINARY KALLIKREIN EXCRETION AS A MARKER OF DISTAL TUBULAR EFFECT

被引：28

作者：

BOMPART, G

PECHER, C

PREVOT, D

GIROLAMI, JP

机构：

[1] INSERM U-133, Faculté de Médecine, Toulouse

来源：

TOXICOLOGY LETTERS | 1990年 / 52卷 / 03期

关键词：

Glomerulus; Molybdenum; Proximal and distal enzymuria; Renal failure; Urinary kallikrein;

D O I：

10.1016/0378-4274(90)90039-O

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

In this study we investigated the effect of two molybdenum (Mo) doses (40 and 80 mg/kg/d) on renal function. Neither dose of Mo was able to induce significant hypertension in treated animals. Subchronic exposure to high doses of Mo resulted in a delay in body weight gain associated with mild renal failure marked by a decrease in glomerular filtration. An increase in diuresis and urinary kallikrein excretion associate d with unchanged glycosuria and proximal tubular enzymuria (alanine aminopeptidase and γ-glutamyl transpeptidase) evoked a preferential mild effect at the distal tubule. © 1990.

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页码：293 / 300

页数：8

相关论文

共 19 条

[1] ACTIVATION OF MINERALOCORTICOID AGONIST AND ANTAGONIST SPECIFIC RECEPTORS FROM RAT-KIDNEY [J].

AGARWAL, MK ;

KALIMI, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 143 (01) :398-402

[2] URINARY KALLIKREIN EXCRETION IN GLOMERULONEPHRITIS AND NEPHROTIC SYNDROME [J].

CUMMING, AD ;

ROBSON, JS .

NEPHRON, 1985, 39 (03) :206-210

[3]

FRIBERG L, 1979, HDB TOXICOLOGY METAL, P531

[4] URINARY OUTPUT MODULATION OF ALANINE AMINOPEPTIDASE, GAMMA-GLUTAMYL-TRANSFERASE TRANSPEPTIDASE AND N-ACETYL-BETA-D-GLUCOSAMINIDASE BY CASTRATION AND TESTOSTERONE IN MALE NORMAL RAT [J].

GIROLAMI, JP ;

BASCANDS, JL ;

PREVOT, D ;

PECHER, C ;

MANUEL, Y .

ENZYME, 1989, 41 (04) :181-186

[5] INVERSE RELATIONSHIP BETWEEN RENAL AND URINARY KALLIKREIN DURING CHROMATE-INDUCED ACUTE-RENAL-FAILURE IN RAT - URINARY KALLIKREIN EXCRETION AS A POSSIBLE RECOVERY INDEX [J].

GIROLAMI, JP ;

ORFILA, C ;

PECHER, C ;

CABOSBOUTOT, G ;

BASCANDS, JL ;

MOATTI, JP ;

ADAM, A ;

COLLE, A .

BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1989, 370 (12) :1305-1313

[6] DIRECT RADIOIMMUNOASSAY OF ACTIVE AND INACTIVE HUMAN GLANDULAR KALLIKREIN - SOME PHYSIOLOGICAL AND PATHOLOGICAL VARIABILITIES [J].

GIROLAMI, JP ;

PECHER, C ;

BASCANDS, JL ;

CABOSBOUTOT, G ;

VEGAVIDALLE, C ;

COLLE, A ;

ADAM, A ;

SUC, JM .

JOURNAL OF IMMUNOASSAY, 1989, 10 (2-3) :221-236

[7]

GIROLAMI JP, 1990, RENAL PHYSIOL BIOCH, V13, P223

[8] RENAL KALLIKREIN EXCRETION AS A DISTAL NEPHROTOXICITY MARKER DURING CADMIUM EXPOSURE IN RATS [J].

GIROLAMI, JP ;

BASCANDS, JL ;

PECHER, C ;

CABOS, G ;

MOATTI, JP ;

MERCIER, JF ;

HAGUENOER, JM ;

MANUEL, Y .

TOXICOLOGY, 1989, 55 (1-2) :117-129

[9] VALUE OF ENZYME DETERMINATIONS IN URINE FOR THE DIAGNOSIS OF NEPHROTOXICITY IN RATS [J].

HOFMEISTER, R ;

BHARGAVA, AS ;

GUNZEL, P .

CLINICA CHIMICA ACTA, 1986, 160 (02) :163-167

[10]

MARTIN R, 1976, MEDICINA-BUENOS AIRE, V36, P223