EFFECTS OF SOME ADENOSINE-ANALOGS ON MORPHINE-INDUCED ANALGESIA AND TOLERANCE

被引：29

作者：

CONTRERAS, E

GERMANY, A

VILLAR, M

机构：

[1] Farmacologia, Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas y de Recursos Naturales, Concepción

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1990年 / 21卷 / 05期

关键词：

D O I：

10.1016/0306-3623(90)91031-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The analogs of adenosine d- and l-phenylisopropyladenosine (d- and l-PIA) and chloroadenosine (CADO) induced analgesia in mice (hot-plate test). 2. The antinociceptive effects of the three adenosine agonists were antagonized by caffeine but were unaffected by naloxone. 3. Morphine-induced antinociception was increased by pretreatment with adenosine agonists. 4. Whereas CADO significantly attenuated the induction of morphine tolerance, d- and l-PIA did not affect the process. © 1990.

引用

页码：763 / 767

页数：5

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