DETERMINATION OF THE PROSTAGLANDIN-F2-ALPHA CONTENT OF PHARMACEUTICAL PREPARATIONS WITH TRIANGLE PROGRAMMED BROMIMETRIC TITRATION IN FLOWING SOLUTIONS

被引：12

作者：

FEHER, Z ^{[1
]}

NAGY, G ^{[1
]}

TOTH, K ^{[1
]}

PUNGOR, E ^{[1
]}

TOTH, A ^{[1
]}

机构：

[1] CHINOIN PHARMACEUT & CHEM WORKS,BUDAPEST,HUNGARY

来源：

ANALYST | 1979年 / 104卷 / 1239期

关键词：

Biamperometry; Coulometry; Flow-through analysis; Prostaglandin F[!sub]2α[!/sub] determination; Triangle programmed bromimetric titration;

D O I：

10.1039/an9790400560

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A survey of the different methods for prostaglandin analysis is given. The use of bromine as a reagent for the accurate determination of prostaglandin F2α is indicated from its chemical structure. Several reasons, however, hinder the use of classical bromimetry. In this paper the application of a new analytical method, the so-called triangle programmed titration technique, is described for prostaglandin analysis. This method permits the simple and effective use of bromine as a reagent by performing the titration in a continuous-flow system. The reagent is generated coulometrically during the titration. Methods are described for the determination of the prostaglandin F2α content of different pharmaceutical preparations.

引用

页码：560 / 565

页数：6

共 19 条

[1] DETERMINATION OF PROSTAGLANDIN-F2ALPHA AND PROSTAGLANDIN-E2 CONTENTS IN HUMAN CEREBROSPINAL-FLUID BY RADIOISOTOPE DILUTION METHOD [J].