INVITRO INTERACTION OF SIZED AND UNSIZED LIPOSOME VESICLES WITH HIGH-DENSITY LIPOPROTEINS

被引：11

作者：

VEMURI, S ^{[1
]}

YU, CD ^{[1
]}

DEGROOT, JS ^{[1
]}

ROOSDORP, N ^{[1
]}

机构：

[1] COOPER LABS INC,MT VIEW,CA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 09期

关键词：

D O I：

10.3109/03639049009074385

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An in vitro method of interaction of liposome vesicles with high density lipoproteins (HDL) was studied. A formulation of lipids was hydrated, and homogenized with a high shear mixer and designed as "unsized" liposomes. A portion of this preparation was further processed by passing through a polycarbonate membrane and it is labelled as "sized" Both these preparations were incubated with HDL. Destabilization rate of liposome preparations in presence of HDL was determined. Time course of drug release from sized and unsized liposomes was followed upon HDL addition to liposomes. These in vitro studies clearly showed that HDL destabilized the small sized liposomes (0.25 ± 0.09 Hm). The destabilization effect of HDL on unsized is not significant. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：1579 / 1584

页数：6

共 9 条

[1] A STUDY OF PHOSPHOLIPID INTERACTIONS BETWEEN HIGH-DENSITY LIPOPROTEINS AND SMALL UNILAMELLAR VESICLES [J].