SERUM IRON LEVELS AND RESPONSE TO HEPATITIS-B VIRUS

被引:51
作者
FELTON, C
LUSTBADER, ED
MERTEN, C
BLUMBERG, BS
机构
关键词
D O I
10.1073/pnas.76.5.2438
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Response to hepatitis B virus (HBV) infection [HBV surface antigen (HBsAg) and antibody to HBsAg (antiHBs)], serum iron, total iron-binding capacity, hematological status (erythrocytes, Hb, and hematocrit), and evidence of liver damage (serum glutamic pyruvic transaminase; aspartate aminotransferase, L-aspartate:2-oxoglutarate aminotransferase, EC 2.6.1.1) were determined for 201 patients on chronic renal dialysis. Four factors - serum iron level, transaminase level, sex, and HBV response [i.e., infected-HBsAg(+) (HBsAg positive), anti-HBs(+)(anti-HBs positive), or no responses] - were analyzed simultaneously to test the hypothesis that serum iron is higher in those with HBsAg in their serum than in those without HBsAg, independent of the transaminase level. Four independent, stastically significant two-factor interactions were identified. (i) Serum iron is higher in those HBsAg(+). (ii) Serum iron is higher in those with increased transaminase. (iii) Transaminase is higher in those HBsAg(+). (iv) Males more likely to be HbsAg(+) and females are more likely to be antiHBs(+). Also, those who are HBsAg(+) have significantly higher percent iron saturation (serum iron/total iron-binding capacity). That is, the hypothesis was supported by the findings. Several additional biological hypotheses are suggested, including a possible role of increased iron levels in susceptibility and response to HBV infection and the possible relationship between higher iron levels and the likelihood of HBV infection progressing to primary hepatocellular carcinoma. In addition, further tests of the initial hypothesis in nonhospitalized populations with endemic HBV infection are proposed.
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页码:2438 / 2441
页数:4
相关论文
共 15 条
[1]  
AISEN P, 1977, SEMIN HEMATOL, V14, P31
[2]  
BROWN MB, 1976, J ROY STAT SOC, V25, P37
[4]  
HENRY RJ, 1960, AM J CLIN PATHOL, V34, P381
[5]  
JACOBS A, 1977, SEMIN HEMATOL, V14, P89
[6]   SEX-DIFFERENCES IN RESPONSE TO HEPATITIS-B INFECTION AMONG PATIENTS RECEIVING CHRONIC DIALYSIS TREATMENT [J].
LONDON, WT ;
DREW, JS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (06) :2561-2563
[7]  
MAZZUR S, 1973, P SOC EXP BIOL MED, V142, P327, DOI 10.3181/00379727-142-37016
[8]  
MILLMAN I, 1971, RES COMMUN CHEM PATH, V2, P667
[9]   GLYCOPROTEINS OF NATURAL ORIGIN WITH AN AFFINITY FOR HEPATITIS-B SURFACE-ANTIGEN [J].
MILLMAN, I ;
MCMICHAEL, JC .
INFECTION AND IMMUNITY, 1978, 21 (03) :879-885
[10]  
RASTOGI SP, 1975, AM SOC NEPHROLOGY, V8, P21