COMPARISON OF INVITRO AND INVIVO RELEASE CHARACTERISTICS OF ACETAMINOPHEN FROM GRADIENT MATRIX SYSTEMS

被引：9

作者：

VANBOMMEL, EMG

RAGHOEBAR, M

TUKKER, JJ

机构：

[1] DUPHAR BV,DEPT DRUG DISPOSIT,WEESP,NETHERLANDS

[2] STATE UNIV UTRECHT,FAC PHARM,DEPT PHARMACEUT,UTRECHT,NETHERLANDS

来源：

BIOPHARMACEUTICS & DRUG DISPOSITION | 1991年 / 12卷 / 05期

关键词：

ORAL CONTROLLED DELIVERY; GRADIENT MATRIX SYSTEM; INVIVO INVITRO CORRELATION ACETAMINOPHEN;

D O I：

10.1002/bdd.2510120506

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An effort was made to correlate the in vivo and in vitro release data of acetaminophen from two formulations of a recently developed controlled-release system, the Gradient Matrix System (GMS-1 and GMS-2). The in vivo release curves, obtained by deconvolution of the plasma concentration time plots, showed a small inter-subject variability. GMS-1 with fastest in vitro release also showed fastest in vivo release. A good relationship was only found after time-scaling of the release data.

引用

页码：367 / 373

页数：7

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