THE CASE FOR FRONTOSTRIATAL DYSFUNCTION IN SCHIZOPHRENIA

被引：238

作者：

ROBBINS, TW

机构：

[1] Department of Experimental Psychology, University of Cambridge, Cambridge

来源：

SCHIZOPHRENIA BULLETIN | 1990年 / 16卷 / 03期

关键词：

D O I：

10.1093/schbul/16.3.391

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

A frontostriatal hypothesis of schizophrenia is advanced which takes into account evidence from studies of neurochemical pathology functional imaging, cognitive neuropsychology, and experimental and clinical psychopharmacology, in addition to factor analyses of the symptomatic heterogeneity of this disorder. This evidence is illuminated by the recent characterization of anatomically segregated, functionally distinct corticostriatal loops which provide possible substrates for understanding the significance of functional changes in striatal and cortical dopaminergic activity interacting with other forms of structural pathology in schizophrenia. © 1990 Oxford University Press.

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页码：391 / 402

页数：12

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