CEREBRAL AMYLOID ANGIOPATHY - POSSIBLE RELATIONSHIP TO RHEUMATOID VASCULITIS

被引:50
作者
MANDYBUR, TI
机构
[1] Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, OH
关键词
D O I
10.1212/WNL.29.10.1336
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In three cases of cerebral amyloid angiopathy there was also a chronic cerebral vasculitis characterized by segmental fibrinoid necrosis, chronic adventitial inflammatory infiltrates, obliterative “endarteritis” and hyaline arteriolar change, resembling rheumatoid vasculitis. Two of these cases had rheumatoid arthritis, and one had unspecified “arthritis” at the onset of dementia. Both vasculitis and amyloidosis involved hadrheumatoidthe leptomeningeal and cerebral cortical vessels. In the two autopsy-verified cases, the vascular disease was limited to the brain. In the third case, only a brain biopsy was available. Amyloid-containing neuritic plaques were present in the cerebral cortex in all three cases, but they were abundant only in one, which also showed numerous Alzheimer tangles. © 1979 American Academy of Neurology.
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页码:1336 / 1340
页数:5
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