PRODUCTION OF CYTOKINES BY PERIPHERAL-BLOOD MONOCYTES MACROPHAGES INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)

被引:124
作者
MOLINA, JM
SCHINDLER, R
FERRIANI, R
SAKAGUCHI, M
VANNIER, E
DINARELLO, CA
GROOPMAN, JE
机构
[1] HARVARD UNIV,NEW ENGLAND DEACONESS HOSP,SCH MED,DIV HEMATOL ONCOL,110 FRANCIS ST,BOSTON,MA 02215
[2] TUFTS UNIV,NEW ENGLAND MED CTR,SCH MED,DIV INFECT DIS,BOSTON,MA 02111
关键词
D O I
10.1093/infdis/161.5.888
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The study of monocyte/macrophage functions after human immunodeficiency virus type 1 (HIV-1) infection may help in understanding the pathogenesis of AIDS. The production of four cytokines, tumor necrosis factor alpha (TNFα), interleukin-1β (IL-1β), interleukin-6 (IL-6), and granulocyte-macrophage colony-stimulating factor (GM-CSF), byperipheral bloodmonocytes/macrophages was evaluated after in vitro infection with HIV-l. HIV-1 infection ofthese monocytes/macrophages did not result in release of any of these cytokines. Similarly, treatment of uninfected cells with purified recombinant HIV-1 envelope protein did not result in cytokine production. After stimulation with endotoxin or endotoxin plus interferon-γ, HIV-1-infected monocytes/macrophages produced amounts of TNFα, IL-6, GM-CSF, and IL-1β comparable to that of uninfected cells. HIV-1 infection does not appear to induce or alter cytokine production bymononuclear phagocytes, which retain the capacity to produce these cytokines after endotoxin stimulation. © 1990 by the University of Chicago. All rights reserved.
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页码:888 / 893
页数:6
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