ROLE OF SUPEROXIDE IN RENAL SCARRING FOLLOWING INFECTION BY MANNOSE-SENSITIVE PILIATED BACTERIA

被引:17
作者
MATSUMOTO, T
MIZUNOE, Y
OGATA, N
TANAKA, M
KUMAZAWA, J
机构
[1] Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka
来源
UROLOGICAL RESEARCH | 1991年 / 19卷 / 04期
关键词
PYELONEPHRITIS; RENAL SCARRING; PATHOGENESIS; SERRATIA-MARCESCENS; PILIATION; SUPEROXIDE DISMUTASE; LEUKOCYTES;
D O I
10.1007/BF00305300
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The role of superoxide in scar formation following renal infection caused by mannose-sensitive (MS) piliated strains of bacteria was studied in the experimental pyelonephritis model using female Sprague-Dawley rats. The MS piliated strain stimulated renal scarring to a significantly greater extent than either the non-piliated or MR-piliated strain. Modulation of leukocytes by administering cyclophosphamide to induce neutropenia and colchicine to inhibit leukocyte migration was effective in preventing renal scarring. Treatment with superoxide dismutase during the early stage of infection was also effective in preventing scar formation. Finally, the production of superoxide by rat leukocytes was significantly larger following stimulation by MS piliated than either the nonpiliated or MR piliated strains. These observations suggest that superoxide released from leukocytes plays a critical role in the development of renal scarring following a bacterial infection, especially by MS piliated strains.
引用
收藏
页码:229 / 233
页数:5
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