THE EFFECT OF CARBOPLATIN ON RENAL-FUNCTION IN PATIENTS WITH METASTATIC GERM-CELL TUMORS

被引：8

作者：

MASON, MD ^{[1
]}

NICHOLLS, J ^{[1
]}

HORWICH, A ^{[1
]}

机构：

[1] ROYAL MARSDEN HOSP,TESTICULAR TUMOUR UNIT,SUTTON SM2 5PT,SURREY,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1991年 / 63卷 / 04期

关键词：

D O I：

10.1038/bjc.1991.144

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Renal function was determined before and at varying times after chemotherapy in 62 patients with metastatic germ cell tumours treated with carboplatin. Eighteen patients were excluded because of urinary tract obstruction, leaving 44 evaluable patients treated with carboplatin either as a single agent (13 patients) or in combination with other agents (31 patients). No significant differences were observed in mean Cr-51-labelled Ethylenediamine tetraacetic acid (EDTA) clearances before and after carboplatin in either the group as a whole (P = 0.58), or when assessment at 1 month or less (P = 0.4), 3 months or less (P = 0.91), or later than 3 months (P = 0.38) were analysed. Carboplatin does not have significant renal toxicity when used at conventional dosage in patients with germ cell tumours.

引用

页码：630 / 633

页数：4

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