ANALYSIS OF SULFONAMIDES USING SUPERCRITICAL FLUID CHROMATOGRAPHY AND SUPERCRITICAL FLUID CHROMATOGRAPHY MASS-SPECTROMETRY

被引:38
作者
PERKINS, JR
GAMES, DE
STARTIN, JR
GILBERT, J
机构
[1] UNIV COLL SWANSEA, DEPT CHEM, MASS SPECTROMETRY RES UNIT, SWANSEA SA2 8PP, W GLAM, WALES
[2] MAFF, FOOD SCI UNIT, NORWICH, ENGLAND
来源
JOURNAL OF CHROMATOGRAPHY | 1991年 / 540卷 / 1-2期
关键词
D O I
10.1016/S0021-9673(01)88813-0
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Packed-column supercritical fluid chromatography has been used for the separation of mixtures of sulphonamides on silica and amino-bonded stationary phases utilizing carbon dioxide with methanol modifier as the mobile phase. The effect of modifier concentration, column pressure and modifier identity on retention was also studied. Packed-column supercritical fluid chromatography-mass spectrometry (SFC-MS) of these mixtures utilizing both moving-belt and modified thermospray interfaces was also studied. The identification of sulphamethazine in a spiked porcine kidney extract was performed by SFC-MS using the moving-belt interface.
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页码:239 / 256
页数:18
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